As people age, systemic inflammation can inflict degenerative effects throughout the body.1-5 A primary cause of this destructive cascade is the production of cell-signaling chemicals known as inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins also contribute to inflammatory processes.

The typical American diet is loaded with foods that contain arachidonic acid (like egg yolk, red meat, poultry, and dairy products) or stimulate the production of excess arachidonic acid in the body (foods rich in highglycemic carbohydrates, saturated fats, and omega-6 fatty acids).

Scientific studies show that excess arachidonic acid increases levels of the 5-lipoxygenase (5-LOX) enzyme, which can induce undesirable effects in cells.* This culminates in the excess accumulation of leukotriene B4, a pro-inflammatory compound that attacks the joints, the arterial wall, and other tissues.*

In India, extracts from the Boswellia plant have been used for centuries as fluid balancing agents.71 Recent human studies have confirmed that a specific Boswellia extract known as AKBA (3-O-acetyl-11-keto-ß-boswellic acid) selectively inhibits 5-LOX.72 Unlike other boswellic acids that only partially inhibit 5-LOX,72,73 AKBA binds directly to 5-LOX, effectively suppressing its proinflammatory activity.

5-LOXIN is a registered trademark of P.L. Thomas & Co., Inc. U.S. patents pending.