Life Extension has long warned members about the dangers of highhomocysteine and has advised taking vitamin B6, folic acid, and vitaminB12 to help maintain healthy arteries.*

Not only have large human trials linked high homocysteine with adramatically greater risk of heart problems, but more recent studiesassociate high homocysteine with an increased incidence ofneurodegenerative issues.*

While many doctors and blood laboratories consider homocysteinelevels of 5-15 micromoles per liter (mmol/L) blood to be "normal,"epidemiologic data indicate that levels above 6.3 mmol/L sharply andprogressively increase heart problems.1 One study found that each 3 mmol/L increase in homocysteine caused a 35 percent increase in heart problems.2Because there is no "safe" level of homocysteine, Life Extensionrecommends keeping levels as low as possible, preferably below 7-8mmol/L.

For those seeking to lower their homocysteine, Homocysteine Resistprovides a potent dose of 750 mg vitamin B6 along with 800 microgramsfolic acid and 500 micrograms vitamin B12.

1. Robinson K, Mayer EL, Miller DP, et al.Hyperhomocysteinemia and low pyridoxal phosphate. Common andindependent reversible risk factors for coronary artery disease.Circulation. 1995 Nov 15:92(10):2825-30.
2. Verhoef P, StamplerMJ, Buring JE, et al. Homocysteine metabolism and risk of myocardialinfarction: relation with vitamins B6, B12, and folate. Am J Epidemiol.1996 May 1; 143(9):845-59.

Do not use this product if your homocysteine levels are at or belowacceptable levels. Consuming more than 2000 mg of vitamin B6 daily canresult in loss of muscle coordination and tingling sensations in theextremities, and degeneration of nerve tissue. Similar effects may beexperienced if more than 200-300 mg of B6 is consumed per day over thecourse of months or years especially if taken without other B complexvitamins. Consult your physician before using this product if you aretaking levodopa (L-dopa).*